Pros

  • Contains Melatonin and Suntheanine, noted for calming effects in 10% of reviews.
  • Supports behavior improvement in some pets as mentioned in user feedback.

Cons

  • Caused vomiting and diarrhea in some dogs.
  • Some dogs experienced severe health issues, including suspected heart failure.
  • Concerns about negative side effects like bruising and low platelets.
  • Switching to another brand improved health for some pets.

Bottom Line

While Zesty Paws Advanced Calming Bites might offer behavior support benefits due to its inclusion of Melatonin and Suntheanine, some pet owners have reported serious adverse effects such as vomiting and significant health issues. Careful consideration and consultation with a vet are recommended before using this product, especially if your pet has existing health conditions or sensitivities.

Lowest at any Popular Retailer
$19.47 at Walmart
How we researched this

About this review: We pulled together findings from professional reviews and hundreds of user reviews, and cross-referenced them with ShopSavvy's pricing data from 8 retailers to give you the short version.

Where to Buy

Prices last updated: June 24th 2026 4:06 pm
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