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O'Keeffe's Night Treatment Hand Cream - Image 1
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O'Keeffe's

O'Keeffe's Night Treatment Hand Cream

$5.00across 94 retailers
Model: Working HandsColor: WhiteUPC: 722510001307
Lowest price
$7.99 at Amazon
Price seen Mar 15, 2023

Where to Buy

Newest price seen: Dec 19, 2025
RetailerPriceLast seenBuy
C
ccsahjejefd
$5.00May 1, 2023, may have changedBuy Now
M
My Store
$5.00May 1, 2023, may have changedBuy Now
M
My Store
$5.00May 3, 2023, may have changedBuy Now
M
My Store
$5.00May 1, 2023, may have changedBuy Now
B
Blain's Farm & Fleet
$7.19Aug 16, 2022, may have changedBuy Now

Prices are collected from retailer listings; each row shows the date we last saw that price. Return and shipping terms are each store's standard policy from our retailer research (April 2026). Some products and categories have different terms, so check with the store before you buy.

Pros

  • •Provides noticeable improvement for extremely dry, cracked, and painful skin within as little as one night.
  • •Creates long-lasting moisture that doesn’t wash off easily, unlike regular lotions.
  • •Requires only twice-daily application, reducing the need for frequent reapplication after hand washing.
  • •Effective not only for hands but also for feet and other dry skin areas.
  • •Works overnight to deeply hydrate and repair even severely cracked skin, including bleeding and painful knuckles.
  • •The formula contains natural grapefruit and lavender oils and is hypoallergenic, appealing to sensitive skin types.
  • •Leaves no greasy or slick residue after application, making it comfortable to wear even while sleeping.
  • •Using 100% cotton gloves with the cream enhances moisture retention and prevents rubbing off on bedding.
  • •Pleasant scent compared to other heavy-duty healing creams.
  • •Backed by a 100% money-back guarantee, reflecting confidence in its effectiveness.

Cons

  • •Some users wish there was an option to buy the original formula without the "night" blend, which contains shea and almond oils that may cause allergies in sensitive individuals.
  • •The tube size is only 3 ounces, which might not last as long for frequent users with severe dryness.
  • •A few users mentioned a preference for stronger or different scents, though the majority found the fragrance pleasant.
  • •Intense healing might require consistent use—results are visible quickly but ongoing care is necessary to maintain skin health.

Bottom Line

O’Keeffe’s Night Treatment Hand Cream is a powerhouse for anyone battling severely dry, cracked, or painful hands, especially if you want quick overnight relief without a greasy feel. Its hypoallergenic formula with moisturizing oils delivers visible repair fast and shows staying power, making it a favorite among those with chronic dryness or harsh-weather skin woes. If you’re sensitive to shea or almond oils, you might want to look for the original formula or try simpler versions. Overall, this hand cream is a fantastic blend of science-backed moisture and user-friendly comfort, ideal for overnight rescue and maintenance.

Read full expert review

What Reviewers Are Saying

Praised
pleasant scent10%
not greasy or slick10%
heals cracked skin20%
transformed my hands20%
works good10%
helps extremely dry skin10%
left hands feeling amazing10%
lasts a long time on the skin10%
using it on my feet20%

Discussion

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