Yes and no. Let me give you the honest answer here.
Can you connect the Sony WF-1000XM6 to your PS5? Absolutely. Go to Settings → Accessories → Bluetooth Accessories, put the earbuds in pairing mode, and they'll connect just fine.
But here's the catch:
PS5's Bluetooth has pretty noticeable audio delay—somewhere between 100 and 200 milliseconds. That might not sound like much, but in practice, you'll hear your gunshot a beat after you pull the trigger. In rhythm games, the timing will feel completely off. Fighting games become almost unplayable.
So what's the XM6's fancy Low Latency mode for? Well, it requires LE Audio support, which the PS5 just... doesn't have. Sony (ironically) built the INZONE Buds specifically for PlayStation gaming, with a special USB dongle that bypasses all these Bluetooth limitations.
When the XM6 actually works great on PS5:
Single-player games where timing doesn't matter. Story-driven adventures, exploration games, RPGs—the slight audio delay won't bother you at all. Plus, that incredible noise cancellation blocks out roommates, family, traffic, whatever. Total immersion.
What to do if you're serious about gaming audio:
Your best bet is either Sony's INZONE Buds (designed exactly for this), a USB Bluetooth adapter that supports aptX Low Latency, or just plug regular headphones into your DualSense controller's headphone jack. Zero latency that way, and honestly, it sounds great.
The WF-1000XM6 is amazing for basically everything else, but PlayStation gaming isn't really its strong suit. That's not a flaw—it's just not what these earbuds were designed for.